What is PT-141?
PT-141 (Bremelanotide) is a synthetic peptide derived from Melanotan II, specifically developed for sexual dysfunction. Unlike PDE5 inhibitors that work on blood flow, PT-141 works centrally through melanocortin receptors in the brain, affecting sexual desire and arousal.
PT-141 is FDA-approved (as Vyleesi®) for premenopausal women with hypoactive sexual desire disorder. Research has also explored its effects in men.
The 10mg vial provides 5-20 doses depending on protocol.
Quick Reference
| Parameter | Value |
|---|---|
| Peptide Amount | 10mg |
| Recommended BAC Water | 2mL |
| Resulting Concentration | 5mg/mL |
| Typical Research Dose | 0.5-2mg |
| Frequency | As needed (not daily) |
| Timing | 45 min before activity |
Reconstitution Guide
Step-by-Step Instructions
- Clean vial stoppers — Wipe with alcohol swabs
- Draw 2mL BAC water — Using sterile syringe
- Add to peptide vial — Inject slowly down the wall
- Dissolve — Gently swirl, 2-5 minutes
- Label and refrigerate — Store immediately
Concentration Calculations
With 10mg in 2mL BAC water:
- Concentration: 5mg/mL = 5000mcg/mL
- Per unit (U-100): 50mcg per unit
Dosage Protocol
Common Dose Calculations
| Desired Dose | Draw Volume | Syringe Units |
|---|---|---|
| 0.5mg (500mcg) | 0.10mL | 10 units |
| 1mg | 0.20mL | 20 units |
| 1.5mg | 0.30mL | 30 units |
| 2mg | 0.40mL | 40 units |
Doses Per Vial
| Dose | Doses Per Vial |
|---|---|
| 0.5mg | 20 doses |
| 1mg | 10 doses |
| 2mg | 5 doses |
Suggested Protocols
Protocol A: Conservative
- Dose: 0.5-1mg
- Timing: 45 min before anticipated activity
- Frequency: Maximum 1x per 24 hours
Protocol B: Standard
- Dose: 1-1.75mg
- Timing: 45 min before
- Frequency: Maximum 8x per month
Important Guidelines
- Not for daily use — Maximum 8 doses per month
- Timing: Effects begin ~45 minutes, last several hours
- Food: May cause nausea; light meal may help
- Blood pressure: May transiently increase
Storage Requirements
| Form | Temperature | Duration |
|---|---|---|
| Lyophilized | -20°C | 2+ years |
| Reconstituted | 2-8°C | 4 weeks |
Research Considerations
Mechanism of Action
- MC3R/MC4R activation — Melanocortin receptors
- Central nervous system — Brain-based action
- Dopamine pathways — Desire and arousal
- Not vascular — Different from Viagra/Cialis
PT-141 vs PDE5 Inhibitors
| Factor | PT-141 | Viagra/Cialis |
|---|---|---|
| Mechanism | Central (brain) | Peripheral (blood flow) |
| Affects desire | Yes | No |
| Works in women | Yes (FDA approved) | Limited |
| Onset | ~45 min | 30-60 min |
| Duration | Several hours | 4-36 hours |
PT-141 vs Melanotan II
| Factor | PT-141 | Melanotan II |
|---|---|---|
| Primary use | Sexual function | Tanning |
| Tanning effect | Minimal | Strong |
| Nausea | Common | Less common |
| Sexual effects | Strong | Moderate |
Side Effects in Research
- Nausea (most common)
- Flushing
- Headache
- Transient blood pressure increase
Sourcing for Research
Source from verified suppliers that provide third-party testing and certificates of analysis (COA) for each batch. Compare purity documentation, shipping conditions, and batch traceability before purchasing research materials.