What is KPV?
KPV (Lys-Pro-Val) is a tripeptide derived from the C-terminal sequence of alpha-melanocyte stimulating hormone (α-MSH). Despite being just three amino acids, KPV retains the potent anti-inflammatory properties of the full α-MSH molecule without melanogenic (tanning) effects.
KPV works by inhibiting inflammatory signaling pathways, particularly NF-κB, making it a subject of research for various inflammatory conditions including gut inflammation.
The 10mg vial provides 20-50 doses at typical research amounts.
Quick Reference
| Parameter | Value |
|---|---|
| Peptide Amount | 10mg |
| Recommended BAC Water | 2mL |
| Resulting Concentration | 5mg/mL |
| Typical Research Dose | 200-500mcg |
| Frequency | Once daily |
| Research Duration | 4-8 weeks |
Reconstitution Guide
Concentration Calculations
With 10mg in 2mL BAC water:
- Concentration: 5mg/mL = 5000mcg/mL
- Per unit (U-100): 50mcg per unit
Dosage Protocol
Common Dose Calculations
| Desired Dose | Draw Volume | Syringe Units |
|---|---|---|
| 200mcg | 0.04mL | 4 units |
| 300mcg | 0.06mL | 6 units |
| 500mcg | 0.10mL | 10 units |
Doses Per Vial
| Dose | Doses | Duration |
|---|---|---|
| 200mcg | 50 doses | 50 days |
| 500mcg | 20 doses | 20 days |
Suggested Protocol
- Dose: 200-500mcg
- Frequency: Once daily
- Duration: 4-8 weeks
Storage Requirements
| Form | Temperature | Duration |
|---|---|---|
| Lyophilized | -20°C | 2+ years |
| Reconstituted | 2-8°C | 4 weeks |
Research Considerations
Mechanism of Action
- NF-κB inhibition — Key inflammatory pathway
- Cytokine modulation — Reduces IL-1β, TNF-α, IL-6
- No melanogenic effect — Unlike full α-MSH
- Gut-specific research — IBD applications
Research Areas
- Inflammatory bowel disease
- Gut inflammation
- General anti-inflammatory
- Wound healing support
KPV in KLOW Blend
KPV is a component of the KLOW blend (GHK-Cu + BPC-157 + TB-500 + KPV), providing anti-inflammatory support alongside healing peptides.
Sourcing for Research
Source from verified suppliers that provide third-party testing and certificates of analysis (COA) for each batch. Compare purity documentation, shipping conditions, and batch traceability before purchasing research materials.