What is Semax?
Semax is a synthetic heptapeptide derived from ACTH (adrenocorticotropic hormone), specifically the 4-10 fragment with a stabilizing Pro-Gly-Pro sequence. Developed in Russia, it’s approved there for stroke, cognitive disorders, and peptic ulcers.
Semax is primarily researched as a nootropic, with effects on BDNF, dopamine, serotonin, and neuroprotection. Unlike ACTH, it doesn’t affect cortisol or adrenal function.
The 30mg vial provides extended research duration, lasting 25-75 days at typical doses.
Quick Reference
| Parameter | Value |
|---|---|
| Peptide Amount | 30mg |
| Recommended BAC Water | 3mL |
| Resulting Concentration | 10mg/mL |
| Typical Research Dose | 200-600mcg |
| Frequency | 2-3x daily |
| Research Duration | 2-4 weeks |
Reconstitution Guide
Step-by-Step Instructions
- Clean vial stoppers — Wipe with alcohol swabs
- Draw 3mL BAC water — Using sterile syringe
- Add to peptide vial — Inject slowly down the wall
- Dissolve — Gently swirl, 2-5 minutes
- Label and refrigerate — Store immediately
Concentration Calculations
With 30mg in 3mL BAC water:
- Concentration: 10mg/mL = 10,000mcg/mL
- Per unit (U-100): 100mcg per unit
Dosage Protocol
Common Dose Calculations
| Desired Dose | Draw Volume | Syringe Units |
|---|---|---|
| 200mcg | 0.02mL | 2 units |
| 400mcg | 0.04mL | 4 units |
| 600mcg | 0.06mL | 6 units |
Doses Per Vial
| Dose | Doses | Duration (2x/day) |
|---|---|---|
| 200mcg | 150 | 75 days |
| 400mcg | 75 | ~37 days |
| 600mcg | 50 | 25 days |
Suggested Protocols
Protocol A: Standard Nootropic
- Dose: 200-400mcg
- Frequency: 2-3x daily
- Duration: 2-4 weeks
Protocol B: Enhanced Cognitive
- Dose: 400-600mcg
- Frequency: 2-3x daily
- Duration: 2-4 weeks
Protocol C: Neuroprotection Research
- Dose: 600mcg
- Frequency: 2x daily
- Duration: 10-14 days
Administration Routes
Semax is commonly administered:
- Intranasal — Most common (spray formulation)
- Subcutaneous — Alternative method
Storage Requirements
| Form | Temperature | Duration |
|---|---|---|
| Lyophilized | -20°C | 2+ years |
| Reconstituted | 2-8°C | 2-3 weeks |
Note: Semax is sensitive. Use within 2-3 weeks of reconstitution.
Research Considerations
Mechanism of Action
- BDNF increase — Neuroplasticity and growth
- Dopamine modulation — Focus and motivation
- Serotonin effects — Mood regulation
- NGF expression — Nerve growth factor
- Neuroprotection — Against various stressors
Semax Variants
| Variant | Modification | Notes |
|---|---|---|
| Semax | Standard | Original |
| N-Acetyl Semax | Acetylated | Enhanced stability |
| N-Acetyl Semax Amidate | Acetyl + amide | Longest acting |
Research Areas
- Cognitive enhancement
- Memory and learning
- Neuroprotection
- Stroke recovery
- ADHD research
- Depression (adjunct)
Semax vs Selank
| Factor | Semax | Selank |
|---|---|---|
| Primary | Nootropic | Anxiolytic |
| Stimulating | Mildly | No |
| Best for | Focus, memory | Calm focus, anxiety |
| BDNF | Strong effect | Moderate effect |
Sourcing for Research
Source from verified suppliers that provide third-party testing and certificates of analysis (COA) for each batch. Compare purity documentation, shipping conditions, and batch traceability before purchasing research materials.