What is MOTS-c?
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrial-derived peptide consisting of 16 amino acids. It’s one of the most exciting peptides in longevity research, often called an “exercise mimetic” due to its effects on metabolism and physical performance.
MOTS-c is naturally produced during exercise and declines with age. Research focuses on its effects on metabolic regulation, insulin sensitivity, and exercise capacity.
The 5mg vial provides 1-2 doses at typical research amounts.
Quick Reference
| Parameter | Value |
|---|---|
| Peptide Amount | 5mg |
| Recommended BAC Water | 1mL |
| Resulting Concentration | 5mg/mL |
| Typical Research Dose | 5-10mg |
| Frequency | 3-5x weekly |
| Research Duration | 4-8 weeks |
Reconstitution Guide
Step-by-Step Instructions
- Clean vial stoppers — Wipe with alcohol swabs
- Draw 1mL BAC water — Using sterile syringe
- Add to peptide vial — Inject slowly down the wall
- Dissolve — Gently swirl, 2-5 minutes
- Label and refrigerate — Store immediately
Concentration Calculations
With 5mg in 1mL BAC water:
- Concentration: 5mg/mL
- Per unit (U-100): 50mcg per unit
Dosage Protocol
Common Dose Calculations
| Desired Dose | Draw Volume | Syringe Units |
|---|---|---|
| 5mg | 1.00mL | 100 units (full vial) |
Doses Per Vial
| Dose | Doses Per Vial |
|---|---|
| 5mg | 1 dose |
Note: The 5mg vial is essentially single-use. Consider 10mg vials for multi-dose protocols.
Suggested Protocols
Protocol A: Standard
- Dose: 5mg
- Frequency: 3x weekly
- Duration: 4-8 weeks
Protocol B: Pre-Exercise
- Dose: 5mg
- Timing: 30-60 min before exercise
- Frequency: Training days only
Storage Requirements
| Form | Temperature | Duration |
|---|---|---|
| Lyophilized | -20°C | 2+ years |
| Reconstituted | 2-8°C | 2-3 weeks |
Note: MOTS-c is more sensitive than some peptides. Use within 2-3 weeks.
Research Considerations
Mechanism of Action
- AMPK activation — Metabolic master switch
- Mitochondrial function — Energy production
- Glucose metabolism — Insulin sensitivity
- Exercise mimetic — Similar to exercise effects
Research Areas
- Metabolic health
- Exercise performance
- Aging and longevity
- Insulin sensitivity
- Mitochondrial function
Sourcing for Research
Source from verified suppliers that provide third-party testing and certificates of analysis (COA) for each batch. Compare purity documentation, shipping conditions, and batch traceability before purchasing research materials.