What is MOTS-c?
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrial-derived peptide known as an “exercise mimetic.” It’s naturally produced during exercise, declines with age, and has shown effects on metabolism, insulin sensitivity, and physical performance.
The 10mg vial is the better value option, providing 2 doses at standard amounts.
Quick Reference
| Parameter | Value |
|---|---|
| Peptide Amount | 10mg |
| Recommended BAC Water | 2mL |
| Resulting Concentration | 5mg/mL |
| Typical Research Dose | 5-10mg |
| Frequency | 3-5x weekly |
| Research Duration | 4-8 weeks |
Reconstitution Guide
Step-by-Step Instructions
- Clean vial stoppers — Wipe with alcohol swabs
- Draw 2mL BAC water — Using sterile syringe
- Add to peptide vial — Inject slowly down the wall
- Dissolve — Gently swirl, 2-5 minutes
- Label and refrigerate — Store immediately
Concentration Calculations
With 10mg in 2mL BAC water:
- Concentration: 5mg/mL
- Per unit (U-100): 50mcg per unit
Dosage Protocol
Common Dose Calculations
| Desired Dose | Draw Volume | Syringe Units |
|---|---|---|
| 5mg | 1.00mL | 100 units |
| 10mg | 2.00mL | Full vial |
Doses Per Vial
| Dose | Doses Per Vial | Duration |
|---|---|---|
| 5mg | 2 doses | ~1 week (3x protocol) |
| 10mg | 1 dose | 1 dose |
Suggested Protocols
Protocol A: Standard
- Dose: 5mg
- Frequency: 3-5x weekly
- Duration: 4-8 weeks
- Vials needed: 6-10 per 4-week cycle
Protocol B: Exercise Enhancement
- Dose: 5-10mg
- Timing: 30-60 min pre-workout
- Frequency: Training days
- Duration: 4-8 weeks
Storage Requirements
| Form | Temperature | Duration |
|---|---|---|
| Lyophilized | -20°C | 2+ years |
| Reconstituted | 2-8°C | 2-3 weeks |
Important: MOTS-c is sensitive. Use within 2-3 weeks of reconstitution.
Research Considerations
Mechanism of Action
- AMPK activation — Key metabolic regulator
- Mitochondrial biogenesis — Energy production
- Glucose uptake — Insulin-independent pathways
- Fat oxidation — Metabolic enhancement
Why 10mg vs 5mg
| Factor | 5mg Vial | 10mg Vial |
|---|---|---|
| Doses at 5mg | 1 | 2 |
| Cost efficiency | Lower | Higher |
| Best for | Single dose | Weekly protocol |
Sourcing for Research
Source from verified suppliers that provide third-party testing and certificates of analysis (COA) for each batch. Compare purity documentation, shipping conditions, and batch traceability before purchasing research materials.