What is Kisspeptin?
Kisspeptin is a neuropeptide encoded by the KISS1 gene that plays a crucial role in reproductive hormone regulation. It acts on the hypothalamus to stimulate GnRH (gonadotropin-releasing hormone) release, which in turn triggers LH and FSH secretion.
Discovered as a key regulator of puberty onset, kisspeptin research has expanded into fertility, sexual function, and hormonal regulation. It represents the “master switch” for the reproductive axis.
The 10mg vial provides multiple doses for research protocols.
Quick Reference
| Parameter | Value |
|---|---|
| Peptide Amount | 10mg |
| Recommended BAC Water | 2mL |
| Resulting Concentration | 5mg/mL |
| Typical Research Dose | 1-5mcg/kg |
| Frequency | Protocol dependent |
| Research Duration | Variable |
Reconstitution Guide
Concentration Calculations
With 10mg in 2mL BAC water:
- Concentration: 5mg/mL = 5000mcg/mL
- Per unit (U-100): 50mcg per unit
Dosage Protocol
Weight-Based Dosing
| Body Weight | 1mcg/kg | 5mcg/kg |
|---|---|---|
| 60kg | 60mcg | 300mcg |
| 80kg | 80mcg | 400mcg |
| 100kg | 100mcg | 500mcg |
Common Dose Calculations
| Desired Dose | Draw Volume | Syringe Units |
|---|---|---|
| 100mcg | 0.02mL | 2 units |
| 250mcg | 0.05mL | 5 units |
| 500mcg | 0.10mL | 10 units |
Doses Per Vial
| Dose | Doses Per Vial |
|---|---|
| 100mcg | 100 doses |
| 500mcg | 20 doses |
Protocol Considerations
Kisspeptin protocols vary significantly based on research goals:
- Single bolus — Acute hormone response studies
- Pulsatile — Mimicking natural secretion
- Continuous — Sustained effects
Storage Requirements
| Form | Temperature | Duration |
|---|---|---|
| Lyophilized | -20°C | 2+ years |
| Reconstituted | 2-8°C | 2-3 weeks |
Note: Kisspeptin is relatively fragile. Use promptly after reconstitution.
Research Considerations
Mechanism of Action
- GnRH stimulation — Primary effect on hypothalamus
- LH/FSH release — Downstream pituitary effects
- Reproductive axis — Master regulator
- Puberty trigger — Developmental role
Research Areas
- Reproductive endocrinology
- Fertility research
- Hypogonadism
- Sexual function
- Puberty disorders
- Hormone axis research
Kisspeptin vs Other Peptides
| Factor | Kisspeptin | PT-141 | GnRH |
|---|---|---|---|
| Mechanism | GnRH release | MC receptors | Direct pituitary |
| LH increase | Yes | No | Yes |
| Sexual function | Indirect | Direct | No |
| Primary use | Hormone research | Sexual function | Fertility |
Important Notes
- Effects are highly dependent on timing and pulsatility
- Continuous exposure may cause desensitization
- Research protocols are specialized
Sourcing for Research
Source from verified suppliers that provide third-party testing and certificates of analysis (COA) for each batch. Compare purity documentation, shipping conditions, and batch traceability before purchasing research materials.