What is DSIP?
DSIP (Delta Sleep-Inducing Peptide) is a neuropeptide that was first isolated from rabbit brain tissue in 1977. It’s named for its ability to induce delta wave sleep — the deep, restorative stage of sleep associated with physical recovery and memory consolidation.
Beyond sleep, DSIP research has expanded to include stress response, pain modulation, and hormonal regulation. It appears to work through multiple mechanisms including GABA modulation and cortisol regulation.
The 5mg vial provides 25-50 doses at typical research amounts.
Quick Reference
| Parameter | Value |
|---|---|
| Peptide Amount | 5mg |
| Recommended BAC Water | 2mL |
| Resulting Concentration | 2.5mg/mL |
| Typical Research Dose | 100-200mcg |
| Frequency | Once daily (evening) |
| Research Duration | 2-4 weeks |
Reconstitution Guide
Step-by-Step Instructions
- Clean vial stoppers — Wipe with alcohol swabs
- Draw 2mL BAC water — Using sterile syringe
- Add to peptide vial — Inject slowly down the wall
- Dissolve — Gently swirl, 2-5 minutes
- Label and refrigerate — Store immediately
Concentration Calculations
With 5mg in 2mL BAC water:
- Concentration: 2.5mg/mL = 2500mcg/mL
- Per unit (U-100): 25mcg per unit
Dosage Protocol
Common Dose Calculations
| Desired Dose | Draw Volume | Syringe Units |
|---|---|---|
| 100mcg | 0.04mL | 4 units |
| 150mcg | 0.06mL | 6 units |
| 200mcg | 0.08mL | 8 units |
Doses Per Vial
| Dose | Doses | Duration |
|---|---|---|
| 100mcg | 50 doses | 50 days |
| 200mcg | 25 doses | 25 days |
Suggested Protocols
Protocol A: Sleep Focus
- Dose: 100-200mcg
- Timing: 30-60 min before bed
- Duration: 2-4 weeks
- Cycling: On 2-4 weeks, off 2 weeks
Protocol B: Stress Research
- Dose: 100mcg
- Timing: Evening
- Duration: 2-4 weeks
Important Notes
- DSIP is typically cycled to prevent tolerance
- Not for continuous long-term use
- Effects may build over several days
Storage Requirements
| Form | Temperature | Duration |
|---|---|---|
| Lyophilized | -20°C | 2+ years |
| Reconstituted | 2-8°C | 3-4 weeks |
Research Considerations
Mechanism of Action
- Delta wave induction — Deep sleep enhancement
- GABA modulation — Calming neurotransmission
- Cortisol regulation — Stress response
- LH modulation — Hormonal effects
- Pain modulation — Analgesic properties
Research Areas
- Sleep quality and architecture
- Stress and anxiety
- Cortisol regulation
- Pain research
- Hormonal balance
DSIP vs Other Sleep Aids
| Factor | DSIP | Melatonin | Pharma Sleep Aids |
|---|---|---|---|
| Mechanism | Delta waves | Circadian | GABA |
| Natural | Yes (endogenous) | Yes | No |
| Dependency risk | Low | Low | Higher |
| Deep sleep | Yes | Indirect | Variable |
Sourcing for Research
Source from verified suppliers that provide third-party testing and certificates of analysis (COA) for each batch. Compare purity documentation, shipping conditions, and batch traceability before purchasing research materials.