What is HGH Fragment 176-191?
HGH Fragment 176-191 is the C-terminal fragment of growth hormone (residues 176-191), the region associated with the fat-mobilising (“lipolytic”) activity of GH. It is studied for stimulating lipolysis without the glucose-handling or IGF-1 effects of full growth hormone. This is the raw fragment; the stabilised analog AOD-9604 is the version that reached human obesity trials.
Reconstitution
HGH Fragment 176-191 reconstitutes with bacteriostatic water. On a 2mg vial, 1mL keeps the solution concentrated enough that research doses stay small draws rather than half-syringe volumes. Draw 1mL down the inside wall of the vial, swirl gently until fully dissolved, and refrigerate. Do not shake.
Quick Reference
| Parameter | Value |
|---|---|
| Peptide Amount | 2mg |
| Reconstitution Solvent | Bacteriostatic water |
| Recommended Volume | 1mL |
| Resulting Concentration | 2mg/mL |
| Typical Research Dose | 250-500mcg |
| Frequency | 1-3x daily (fasted) |
Reconstitution Guide
Materials Needed
- HGH Fragment 176-191 2mg lyophilized vial
- Bacteriostatic water (BAC water)
- Insulin syringes (U-100, 29-31 gauge)
- Alcohol swabs
- Sharps container
Step-by-Step Instructions
- Prepare workspace — Clean environment, gather materials, thorough handwashing.
- Clean vial stoppers — Wipe both vials with alcohol swabs. Allow complete drying.
- Draw BAC water — Draw 1mL bacteriostatic water using a sterile syringe.
- Add to peptide — Inject slowly down the inside wall of the vial. Do not spray directly onto the powder.
- Dissolve — Allow a few minutes for complete dissolution. Gentle swirl only — no shaking.
- Verify — Solution should be clear.
- Label and store — Note reconstitution date. Refrigerate immediately.
Dosage Protocol
Concentration Calculations
With 2mg peptide in 1mL BAC water:
- Concentration: 2mg/mL (2000mcg/mL)
- Per unit (U-100 syringe): 20mcg per unit
Run your exact vial and water combination through the peptide reconstitution calculator to rebuild this table for your setup.
Common Dose Calculations
| Desired Dose | Draw Volume | Syringe Units |
|---|---|---|
| 250mcg | 0.125mL | 12.5 units |
| 300mcg | 0.15mL | 15 units |
| 500mcg | 0.25mL | 25 units |
At this strength the 2mg vial holds four 500mcg draws, or eight at 250mcg — worth planning around, since the reconstituted window is only 2-3 weeks.
Research Considerations
Mechanism
The fragment is thought to act on the beta-3 adrenergic pathway of adipose tissue to promote fat breakdown while sparing the growth-promoting signalling of the intact hormone.
Sourcing for Research
Source from verified suppliers that provide third-party testing and certificates of analysis (COA) for each batch. Compare purity documentation, shipping conditions, and batch traceability before purchasing research materials.
Storage Requirements
Lyophilized (Powder)
- Temperature: -20°C or colder
- Duration: 2+ years
- Conditions: Dry, dark, protected from moisture
Reconstituted
- Temperature: 2-8°C (refrigerated)
- Duration: 2-3 weeks
- Conditions: Protected from light, never freeze
Safety Considerations
- HGH Fragment 176-191 is a research compound
- Not approved for any indication in any jurisdiction
- Research use only — not for human consumption
- Use sterile technique; never reuse needles or syringes
Scientific References
- Research literature on HGH Fragment 176-191 and its proposed mechanism of action.
- Peer-reviewed and preclinical sources on the compound class discussed above.
Last updated: 2026-07-21.
Disclaimer: This information is for educational and research purposes only. HGH Fragment 176-191 is a research compound and is not approved for any use. Research-grade peptides are not intended for human consumption. Always follow applicable laws and institutional guidelines.