What is Hexarelin?
Hexarelin (Examorelin) is a synthetic hexapeptide growth hormone secretagogue and one of the most potent GHRPs available. It produces very strong GH release through ghrelin receptor (GHS-R1a) activation, making it popular for research requiring maximum GH stimulation.
Hexarelin is notable for its strength but also for causing more pronounced increases in cortisol and prolactin compared to other GHRPs. It can also lead to desensitization with prolonged use, requiring cycling strategies.
The 5mg vial provides several weeks of research at standard doses.
Quick Reference
| Parameter | Value |
|---|---|
| Peptide Amount | 5mg |
| Recommended BAC Water | 2mL |
| Resulting Concentration | 2.5mg/mL (2500mcg/mL) |
| Typical Research Dose | 100-200mcg |
| Frequency | 2-3x daily |
| Research Duration | 4-8 weeks (cycling recommended) |
Hexarelin Characteristics
| Effect | Level | Notes |
|---|---|---|
| GH Release | Very Strong | Strongest GHRP |
| Cortisol | Moderate | More than GHRP-2 |
| Prolactin | Moderate | More than GHRP-2 |
| Appetite | Mild | Less than GHRP-6 |
| Desensitization | Yes | Cycling recommended |
Reconstitution Guide
Materials Needed
- Hexarelin 5mg lyophilized vial
- Bacteriostatic water (BAC water)
- Insulin syringes (U-100, 29-31 gauge)
- Alcohol swabs
- Sharps container
Step-by-Step Instructions
-
Prepare workspace — Clean area, wash hands.
-
Clean vial stoppers — Wipe with alcohol swabs.
-
Draw BAC water — Draw 2mL of bacteriostatic water.
-
Add to peptide vial — Inject slowly down the inside wall.
-
Dissolve — Hexarelin dissolves within 2-5 minutes.
-
Verify — Solution should be clear and colorless.
-
Label and refrigerate — Store immediately.
Alternative Reconstitution
| BAC Water | Concentration | Best For |
|---|---|---|
| 2mL | 2.5mg/mL | Standard |
| 2.5mL | 2mg/mL | Easy calculations |
| 5mL | 1mg/mL | Precise measuring |
Dosage Protocol
Concentration Calculations
With 5mg peptide in 2mL BAC water:
- Concentration: 2.5mg/mL = 2500mcg/mL
- Per unit (U-100 syringe): 25mcg per unit
Common Dose Calculations
| Desired Dose | Draw Volume | Syringe Units |
|---|---|---|
| 50mcg | 0.02mL | 2 units |
| 100mcg | 0.04mL | 4 units |
| 150mcg | 0.06mL | 6 units |
| 200mcg | 0.08mL | 8 units |
Doses Per Vial
At 2.5mg/mL concentration (2mL total = 5mg):
| Protocol | Dose | Injections | Duration |
|---|---|---|---|
| 100mcg 2x/day | 100mcg | 50 | 25 days |
| 100mcg 3x/day | 100mcg | 50 | ~17 days |
| 200mcg 2x/day | 200mcg | 25 | ~12 days |
Suggested Research Protocols
Protocol A: Conservative
- Dose: 100mcg
- Frequency: 2x daily
- Duration: 4-6 weeks
- Then: 2-4 week break
Protocol B: Standard
- Dose: 100-200mcg
- Frequency: 2-3x daily
- Duration: 4-8 weeks
- Then: 4 week break
Protocol C: With GHRH
- Hexarelin: 100mcg
- CJC-1295: 100mcg
- Frequency: 2-3x daily
- Duration: 4-8 weeks
Cycling Recommendation
Hexarelin can cause desensitization of the ghrelin receptor with prolonged use:
| Cycle Pattern | On Period | Off Period |
|---|---|---|
| Conservative | 4 weeks | 2 weeks |
| Standard | 6 weeks | 4 weeks |
| Extended | 8 weeks | 4-6 weeks |
Signs of desensitization:
- Reduced GH response
- Diminished effects
- Need for higher doses (not recommended)
Injection Guide
Subcutaneous Administration
- Clean injection site with alcohol swab
- Pinch skin fold at abdomen or thigh
- Insert needle at 45-90° angle
- Inject slowly
- Wait 5 seconds before withdrawing
Timing
Optimal injection times:
- Morning (fasted)
- Post-workout
- Before bed
Always on empty stomach for best response.
Storage Requirements
Lyophilized
- Temperature: -20°C or colder
- Duration: 2+ years
Reconstituted
- Temperature: 2-8°C
- Duration: 3-4 weeks
Research Considerations
Mechanism of Action
Hexarelin works through:
- Strong GHS-R1a binding — Potent ghrelin receptor activation
- Direct pituitary stimulation — Maximum somatotroph response
- Hypothalamic effects — Somatostatin suppression
- Cardiac effects — Studied cardioprotective properties
GHRP Potency Comparison
| Peptide | GH Release | Selectivity |
|---|---|---|
| Hexarelin | +++++ | + |
| GHRP-2 | ++++ | ++ |
| GHRP-6 | +++ | ++ |
| Ipamorelin | +++ | ++++ |
Cardioprotective Research
Hexarelin has been studied for cardiac effects beyond GH release:
- Cardioprotective properties independent of GH
- May involve direct cardiac receptors
- Research area distinct from other GHRPs
When to Choose Hexarelin
Good choice when:
- Maximum GH release is research priority
- Short-term intensive protocols
- Cardiac research applications
- Response to other GHRPs is insufficient
Consider alternatives when:
- Long-term continuous use planned
- Cleaner hormone profile preferred
- Cortisol/prolactin increases undesirable
- Cycling isn’t feasible
Stacking Considerations
Hexarelin + CJC-1295 (no DAC)
- Very potent combination
- Use lower Hexarelin doses (100mcg)
- Monitor for excessive effects
Not recommended to combine:
- Hexarelin + GHRP-2 or GHRP-6
- Redundant mechanism
- Increases side effects without benefit
Sourcing for Research
Source from verified suppliers that provide third-party testing and certificates of analysis (COA) for each batch. Compare purity documentation, shipping conditions, and batch traceability before purchasing research materials.
Scientific References
- Arvat E, et al. “Endocrine Activities of Ghrelin, a Natural Growth Hormone Secretagogue (GHS), in Humans: Comparison and Interactions with Hexarelin.” Eur J Endocrinol. 2001;144(5):517-523.
- Locatelli V, et al. “Hexarelin, a Potent GHRP Analogue: Interactions with GHRH and Clonidine in Young and Aged Dogs.” Eur J Pharmacol. 1994;258(3):201-205.
- Tivesten A, et al. “Growth Hormone-Induced Blood Pressure Decrease Is Associated with Increased mRNA Levels of the Vascular Smooth Muscle KATP Channel.” J Endocrinol. 2004;183(1):195-202.
Last updated: December 23, 2025
Disclaimer: This information is for educational and research purposes only. Hexarelin is a research peptide not intended for human consumption.