What is CJC-1295 with DAC?
CJC-1295 with DAC (Drug Affinity Complex) is a long-acting synthetic GHRH analog. The DAC modification allows the peptide to bind to albumin in the bloodstream, dramatically extending its half-life from ~30 minutes to approximately 8 days.
This extended duration means CJC-1295 DAC can be administered just once or twice weekly while maintaining elevated growth hormone and IGF-1 levels throughout the week.
The 2mg vial provides 1-2 weeks of research depending on dosing protocol.
Quick Reference
| Parameter | Value |
|---|---|
| Peptide Amount | 2mg |
| Recommended BAC Water | 1mL |
| Resulting Concentration | 2mg/mL (2000mcg/mL) |
| Typical Research Dose | 1-2mg weekly |
| Frequency | 1-2x weekly |
| Research Duration | 8-12 weeks |
CJC-1295 DAC vs No DAC
| Feature | With DAC | Without DAC |
|---|---|---|
| Half-life | ~8 days | ~30 minutes |
| Dosing | Weekly | 2-3x daily |
| GH pattern | Sustained elevation | Pulsatile |
| Convenience | High | Lower |
| More natural | No | Yes |
| IGF-1 elevation | Prolonged | Transient |
Reconstitution Guide
Materials Needed
- CJC-1295 DAC 2mg lyophilized vial
- Bacteriostatic water (BAC water)
- Insulin syringes (U-100, 29-31 gauge)
- Alcohol swabs
- Sharps container
Step-by-Step Instructions
-
Prepare your workspace — Clean area, wash hands thoroughly.
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Clean the vial stoppers — Wipe both vials with alcohol swabs. Let dry.
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Draw the BAC water — Draw 1mL of bacteriostatic water.
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Add water to peptide vial — Inject slowly down the inside wall.
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Allow to dissolve — Dissolves within 2-5 minutes. Gently swirl if needed.
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Verify dissolution — Solution should be clear and colorless.
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Label and store — Write reconstitution date. Refrigerate immediately.
Dosage Protocol
Concentration Calculations
With 2mg peptide in 1mL BAC water:
- Concentration: 2mg/mL = 2000mcg/mL
- Per unit (U-100 syringe): 20mcg per unit
Common Dose Calculations
| Desired Dose | Draw Volume | Syringe Units |
|---|---|---|
| 500mcg | 0.25mL | 25 units |
| 1000mcg (1mg) | 0.50mL | 50 units |
| 2000mcg (2mg) | 1.00mL | 100 units (full vial) |
Doses Per Vial
| Weekly Dose | Doses Per Vial | Duration |
|---|---|---|
| 1mg/week | 2 doses | 2 weeks |
| 2mg/week | 1 dose | 1 week |
| 1mg 2x/week | 1 week | 1 week |
Suggested Research Protocols
Protocol A: Standard Weekly
- Dose: 2mg
- Frequency: Once weekly
- Duration: 8-12 weeks
Protocol B: Split Dose
- Dose: 1mg
- Frequency: 2x weekly (e.g., Mon/Thu)
- Duration: 8-12 weeks
Protocol C: With Daily GHRP
- CJC-1295 DAC: 2mg weekly
- Ipamorelin: 200mcg 2x daily
- Duration: 8-12 weeks
Timing Considerations
Unlike CJC-1295 no DAC, timing is less critical due to the long half-life:
- Can be administered any time of day
- Food intake has minimal impact
- Consistent weekly schedule recommended
Injection Guide
Subcutaneous Administration
- Clean injection site with alcohol swab
- Pinch skin fold at abdomen or thigh
- Insert needle at 45-90° angle
- Inject slowly
- Wait 5-10 seconds before withdrawing
- Apply gentle pressure
Site Rotation
With weekly dosing, rotate between:
- Week 1: Left abdomen
- Week 2: Right abdomen
- Week 3: Left thigh
- Week 4: Right thigh
Storage Requirements
Lyophilized (Powder Form)
- Temperature: -20°C (-4°F) or colder
- Duration: 2+ years
- Conditions: Protect from light and moisture
Reconstituted (Mixed with BAC Water)
- Temperature: 2-8°C (36-46°F)
- Duration: 4 weeks
- Conditions: Protect from light, never freeze
Research Considerations
Mechanism of Action
CJC-1295 DAC works through:
- GHRH receptor activation — Same as regular CJC-1295
- Albumin binding — DAC binds to blood albumin
- Extended circulation — ~8 day half-life
- Sustained GH/IGF-1 — Elevated levels throughout week
Pros and Cons of DAC Version
Advantages:
- Convenient weekly dosing
- Sustained GH and IGF-1 elevation
- Less frequent injections
- Easier compliance
Considerations:
- Less natural GH pattern (not pulsatile)
- Constant elevation vs. pulses
- May cause desensitization with long-term use
- Higher per-dose amount needed
Stacking with GHRPs
CJC-1295 DAC can be combined with daily GHRP:
| Stack | Protocol |
|---|---|
| CJC-1295 DAC + Ipamorelin | DAC weekly + Ipam 2x daily |
| CJC-1295 DAC + GHRP-2 | DAC weekly + GHRP-2 2x daily |
The GHRP provides pulsatile release on top of the elevated baseline from DAC.
Expected Research Outcomes
Studies have examined CJC-1295 DAC for:
- Sustained growth hormone elevation
- IGF-1 level maintenance
- Body composition research
- Recovery and regeneration
- Anti-aging protocols
Sourcing for Research
Source from verified suppliers that provide third-party testing and certificates of analysis (COA) for each batch. Compare purity documentation, shipping conditions, and batch traceability before purchasing research materials.
Scientific References
- Teichman SL, et al. “Prolonged Stimulation of Growth Hormone and Insulin-Like Growth Factor I Secretion by CJC-1295.” J Clin Endocrinol Metab. 2006;91(3):799-805.
- Ionescu M, Bhada LP. “Pharmacokinetic Profile of CJC-1295: A Long-Acting Growth Hormone-Releasing Factor Analog.” Drug Metab Pharmacokinet. 2006;21(3):189-195.
Last updated: December 23, 2025
Disclaimer: This information is for educational and research purposes only. CJC-1295 DAC is a research peptide not intended for human consumption. Always follow applicable laws and institutional guidelines.