What is ARA-290?
ARA-290 (cibinetide) is an 11-amino-acid peptide derived from the Helix-B region of erythropoietin. Unlike EPO, it is non-erythropoietic (it does not raise red-cell counts) and acts on the innate repair receptor (IRR). It is studied for small-fibre neuropathy and nerve repair, and holds EU Orphan Drug Designation for sarcoidosis-associated neuropathy.
Reconstitution
ARA-290 reconstitutes with bacteriostatic water. Draw 2mL down the inside wall of the vial, swirl gently until fully dissolved, and refrigerate. Do not shake.
Quick Reference
| Parameter | Value |
|---|---|
| Peptide Amount | 16mg |
| Reconstitution Solvent | Bacteriostatic water |
| Recommended Volume | 2mL |
| Resulting Concentration | 8mg/mL |
| Typical Research Dose | 1-4mg |
| Frequency | daily |
Reconstitution Guide
Materials Needed
- ARA-290 16mg lyophilized vial
- Bacteriostatic water (BAC water)
- Insulin syringes (U-100, 29-31 gauge)
- Alcohol swabs
- Sharps container
Step-by-Step Instructions
- Prepare workspace — Clean environment, gather materials, thorough handwashing.
- Clean vial stoppers — Wipe both vials with alcohol swabs. Allow complete drying.
- Draw BAC water — Draw 2mL bacteriostatic water using a sterile syringe.
- Add to peptide — Inject slowly down the inside wall of the vial. Do not spray directly onto the powder.
- Dissolve — Allow a few minutes for complete dissolution. Gentle swirl only — no shaking.
- Verify — Solution should be clear.
- Label and store — Note reconstitution date. Refrigerate immediately.
Dosage Protocol
Concentration Calculations
With 16mg peptide in 2mL BAC water:
- Concentration: 8mg/mL (8000mcg/mL)
- Per unit (U-100 syringe): 80mcg per unit
Run your exact vial and water combination through the peptide reconstitution calculator to rebuild this table for your setup.
Common Dose Calculations
| Desired Dose | Draw Volume | Syringe Units |
|---|---|---|
| 1mg | 0.13mL | 13 units |
| 2mg | 0.25mL | 25 units |
| 4mg | 0.50mL | 50 units |
Research Considerations
Mechanism
ARA-290 engages the innate repair receptor, a heteromer of the EPO receptor and the beta-common receptor, triggering tissue-protective and anti-inflammatory signalling without erythropoiesis.
Sourcing for Research
Source from verified suppliers that provide third-party testing and certificates of analysis (COA) for each batch. Compare purity documentation, shipping conditions, and batch traceability before purchasing research materials.
Storage Requirements
Lyophilized (Powder)
- Temperature: -20°C or colder
- Duration: 2+ years
- Conditions: Dry, dark, protected from moisture
Reconstituted
- Temperature: 2-8°C (refrigerated)
- Duration: 2-3 weeks
- Conditions: Protected from light, never freeze
Safety Considerations
- ARA-290 is a research compound
- Not approved for any indication in any jurisdiction
- Research use only — not for human consumption
- Use sterile technique; never reuse needles or syringes
Scientific References
- Research literature on ARA-290 and its proposed mechanism of action.
- Peer-reviewed and preclinical sources on the compound class discussed above.
Last updated: 2026-07-20.
Disclaimer: This information is for educational and research purposes only. ARA-290 is a research compound and is not approved for any use. Research-grade peptides are not intended for human consumption. Always follow applicable laws and institutional guidelines.