What is SS-31?
SS-31 (Elamipretide, Bendavia, MTP-131) is a mitochondria-targeted tetrapeptide that selectively concentrates in the inner mitochondrial membrane. It targets cardiolipin, a key phospholipid essential for mitochondrial function and energy production.
SS-31 is being studied for various conditions involving mitochondrial dysfunction, including aging, heart failure, and metabolic disorders. It’s one of the most advanced mitochondrial peptides in clinical development.
The 5mg vial provides multiple doses for research protocols.
Quick Reference
| Parameter | Value |
|---|---|
| Peptide Amount | 5mg |
| Recommended BAC Water | 1mL |
| Resulting Concentration | 5mg/mL |
| Typical Research Dose | 0.1-0.5mg/kg |
| Frequency | Once daily |
| Research Duration | 4-8 weeks |
Reconstitution Guide
Step-by-Step Instructions
- Clean vial stoppers — Wipe with alcohol swabs
- Draw 1mL BAC water — Using sterile syringe
- Add to peptide vial — Inject slowly down the wall
- Dissolve — Gently swirl, 2-5 minutes
- Label and refrigerate — Store immediately
Concentration Calculations
With 5mg in 1mL BAC water:
- Concentration: 5mg/mL
- Per unit (U-100): 50mcg per unit
Dosage Protocol
Common Dose Calculations
| Desired Dose | Draw Volume | Syringe Units |
|---|---|---|
| 500mcg | 0.10mL | 10 units |
| 1mg | 0.20mL | 20 units |
| 2.5mg | 0.50mL | 50 units |
Weight-Based Dosing
For reference (0.25mg/kg example):
- 60kg: ~15mg
- 80kg: ~20mg
- 100kg: ~25mg
Note: Research protocols vary significantly. Dose based on specific study design.
Doses Per Vial
| Dose | Doses Per Vial |
|---|---|
| 500mcg | 10 doses |
| 1mg | 5 doses |
| 2.5mg | 2 doses |
Storage Requirements
| Form | Temperature | Duration |
|---|---|---|
| Lyophilized | -20°C | 2+ years |
| Reconstituted | 2-8°C | 2-3 weeks |
Note: SS-31 is sensitive. Use within 2-3 weeks of reconstitution.
Research Considerations
Mechanism of Action
- Cardiolipin binding — Stabilizes inner mitochondrial membrane
- Electron transport — Optimizes ATP production
- ROS reduction — Decreases reactive oxygen species
- Membrane potential — Maintains mitochondrial function
Research Areas
- Mitochondrial dysfunction
- Cardiac health
- Aging and longevity
- Neurodegenerative conditions
- Metabolic disorders
Clinical Development
SS-31 (as Elamipretide) has been in clinical trials for:
- Barth syndrome
- Heart failure
- Age-related macular degeneration
- Primary mitochondrial myopathy
Sourcing for Research
Source from verified suppliers that provide third-party testing and certificates of analysis (COA) for each batch. Compare purity documentation, shipping conditions, and batch traceability before purchasing research materials.